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Diseases Associated with Transplant

                                                                                  Liver Transplantation: Version 7.0

Diseases That Are Associated With Liver Transplantation





Advanced Chronic Liver Disease


ICD.10: Q44.2, Q44.3, K74.3-K75.9, K83.0,     K70.0 – K74.69, D89.89, I82.0








Predominantly cholestatic disease

Biliary atresia

Primary biliary cirrhosis

Primary sclerosing cholangitis

Familial cholestatic syndromes

Predominantly hepatocellular disease

Chronic viral-induced liver disease (hepatitis B, C, D) ~ 50 percent of all patients

Chronic drug-induced liver disease

Alcoholic liver disease ~ 20  percent of all patients

Idiopathic autoimmune liver disease

Predominantly vascular disease

Budd-Chiari syndrome

Veno-occlusive disease

Unresectable Hepatic Malignancies


ICD10: C22.0 – C22.8

Hepatocellular carcinoma

NOT Cholangiocarcinoma (may be acceptable depending on tumor characteristics.)

Metabolic Liver Disease


ICD10: E78.2, E80.0 – E83.110,

Alpha-1 antitrypsin deficiency

Wilson's disease

Homozygous type II hyperlipoproteinemia

Crigler-Najjar syndrome type I

Erythropoietic protoporphyria

Urea cycle deficiencies

Glycogen storage diseases, type I and IV


Hereditary hemochromatosis

Fulminant Hepatic Failure


ICD10: B15.0 – B19.0, T39.1X1A – T39.1X4A, G96.7, E72.9

Acute viral hepatitis (A; B; D; non-A, non-B; Epstein-Barr virus (EBV))

Drug-induced liver toxicity






Metabolic liver disease

Wilson's disease

Reye's syndrome

Organic acidurias

Retransplant/Graft Failure

           ICD10: T86.40 –T86.42



 ICD10: Z94.4

S/P liver transplant


The conditions associated with liver transplantation in children are similar to adults, but the frequency is different. Biliary atresia is the most common indication for liver transplantation in children followed by a1anti-trypsin deficiency.

1 Manzarbeitia C and Smith SL. “Liver Transplantation.” Organ Transplant 2003. 28 March 2003. 18 June 2003