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Contraindications


                                                                                  Heart Transplantation: Version 7.0

Contraindications

Absolute Contraindications
    •    Fixed pulmonary vascular resistance of greater than four Wood units
    •    Active systemic infection
    •    Active systemic disease, such as collagen vascular disease or sickle cell disease
    •    Active malignancy: Patients with malignancies who have demonstrated a
         three- to five-year disease-free interval may be considered, depending upon
         the tumor type and the evaluating program.
    •    An ongoing history of substance abuse (e.g., alcohol, drugs, tobacco)
    •    HIV positive (may vary at different centers, and becoming more of a relative contraindication)
    •    Psychosocial instability
    •    High risk of life-threatening noncompliance

Relative Contraindications
    •    Age over 70 years: patients who exceed these limits are evaluated on an individual
         basis  Different centers may take different approaches to the older patient
    •    Diabetes mellitus with end-organ damage
    •    Active peptic ulcer disease
    •    Untreated substance abuse
    •    Significant peripheral vascular or cerebral vascular disease
    •    Severe obesity (BMI > 35)
    •    Cachexia
    •    Severe osteoporosis or other systemic disease with poor prognosis
    •    HCV positive (may vary at different centers)